Tissue Specificity | Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen. |
Post Translational Modifications | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
Function | Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. |
Protein Name | Fibronectin Type Iii Domain-Containing Protein 5Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin |
Database Links | |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPeroxisome MembraneImported In Peroxisomes Through The Pex5 Receptor PathwayIrisin: SecretedDetected In The Blood Of Individuals Subjected To Endurance Exercise |
Alternative ELISA Names | Fibronectin Type Iii Domain-Containing Protein 5 ELISA kitFibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin ELISA kitFNDC5 ELISA kitFRCP2 ELISA kit |
output | |
Information sourced from Uniprot.org