Human FKBP1A/FKBP12 protein (Recombinant) (No tag) (STJP000826)

SKU:

STJP000826

£59.50 - £105.50

Host:	E. coli
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human FKBP1A/FKBP12-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of 20mM TRIS, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation.

Gene Symbol:	FKBP1A
Gene ID:	2280
Uniprot ID:	FKB1A_HUMAN
Immunogen:	Recombinant Human FKBP1A/FKBP12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu108) of human FKBP12 (Accession #NP_000792.1).

Function	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a Ppiase Fkbp1a 12 Kda Fk506-Binding Protein 12 Kda Fkbp Fkbp-12 Calstabin-1 Fk506-Binding Protein 1a Fkbp-1a Immunophilin Fkbp12 Rotamase
Database Links	Reactome: R-HSA-166208 Reactome: R-HSA-2025928 Reactome: R-HSA-2173789 Reactome: R-HSA-2173791 Reactome: R-HSA-3656535 Reactome: R-HSA-9679191 Reactome: R-HSA-9692916
Cellular Localisation	Cytoplasm Cytosol Sarcoplasmic Reticulum Membrane Peripheral Membrane Protein Cytoplasmic Side
Alternative Protein Names	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a protein Ppiase Fkbp1a protein 12 Kda Fk506-Binding Protein protein 12 Kda Fkbp protein Fkbp-12 protein Calstabin-1 protein Fk506-Binding Protein 1a protein Fkbp-1a protein Immunophilin Fkbp12 protein Rotamase protein FKBP1A protein FKBP1 protein FKBP12 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance