| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris, 150mM NaCl, pH 8.0. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | FKBP1A |
| Gene ID: | 2280 |
| Uniprot ID: | FKB1A_HUMAN |
| Immunogen: | Recombinant Human FKBP1A/FKBP12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu108) of human FKBP12 (Accession #NP_000792.1). |
| Immunogen Sequence: | MGVQVETISPGDGRTFPKRG QTCVVHYTGMLEDGKKFDSS RDRNKPFKFMLGKQEVIRGW EEGVAQMSVGQRAKLTISPD YAYGATGHPGIIPPHATLVF DVELLKLE |
| Function | Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1aPpiase Fkbp1a12 Kda Fk506-Binding Protein12 Kda FkbpFkbp-12Calstabin-1Fk506-Binding Protein 1aFkbp-1aImmunophilin Fkbp12Rotamase |
| Database Links | Reactome: R-HSA-166208Reactome: R-HSA-2025928Reactome: R-HSA-2173789Reactome: R-HSA-2173791Reactome: R-HSA-3656535Reactome: R-HSA-9679191Reactome: R-HSA-9692916 |
| Cellular Localisation | CytoplasmCytosolSarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp1a proteinPpiase Fkbp1a protein12 Kda Fk506-Binding Protein protein12 Kda Fkbp proteinFkbp-12 proteinCalstabin-1 proteinFk506-Binding Protein 1a proteinFkbp-1a proteinImmunophilin Fkbp12 proteinRotamase proteinFKBP1A proteinFKBP1 proteinFKBP12 protein |
Information sourced from Uniprot.org
