• Human FGF-19 protein (Recombinant) (C-His) (STJP001244)
  • Human FGF-19 protein (Recombinant) (C-His) (STJP001244)
  • Human FGF-19 protein (Recombinant) (C-His) (STJP001244)
  • Human FGF-19 protein (Recombinant) (C-His) (STJP001244)

Human FGF-19 protein (Recombinant) (C-His) (STJP001244)

SKU:
STJP001244

Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human FGF19 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human FGFR4 with a linear range of 0.9-3.8 Mu g/mL.
Gene Symbol: FGF19
Gene ID: 9965
Uniprot ID: FGF19_HUMAN
Immunogen Region: Phe27-Lys216
Immunogen: Recombinant Human FGF-19 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe27-Lys216) of human FGF-19 (Accession #NP_005108.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: FSDAGPHVHYGWGDPIRLRH LYTSGPHGLSSCFLRIRADG VVDCARGQSAHSLLEIKAVA LRTVAIKGVHSVRYLCMGAD GKMQGLLQYSEEDCAFEEEI RPDGYNVYRSEKHRLPVSLS SAKQRQLYKNRGFLPLSHFL PMLPMVPEEPEDLRGHLESD MFSSPLETDSMDPFGLVTGL EAVRSPSFEK
Tissue Specificity Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Function Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Protein Name Fibroblast Growth Factor 19
Fgf-19
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-1307965
Reactome: R-HSA-190322
Reactome: R-HSA-2219530
Reactome: R-HSA-5654228
Reactome: R-HSA-5654712
Reactome: R-HSA-5654719
Reactome: R-HSA-5654720
Reactome: R-HSA-5654733
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Cellular Localisation Secreted
Alternative Protein Names Fibroblast Growth Factor 19 protein
Fgf-19 protein
FGF19 protein
UNQ334 protein
PRO533 protein

Information sourced from Uniprot.org

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