| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.54ng/mL |
| Detection Limit: | 1.56-100ng/mL |
| Short Description: | This FFAR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | FFAR1 |
| Gene ID: | 2864 |
| Uniprot ID: | FFAR1_HUMAN |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Detected in brain and pancreas. Detected in pancreatic beta cells. |
| Post Translational Modifications | |
| Function | G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis.receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. |
| Protein Name | Free Fatty Acid Receptor 1 G-Protein Coupled Receptor 40 |
| Database Links | Reactome: R-HSA-381771 Reactome: R-HSA-400511 Reactome: R-HSA-416476 Reactome: R-HSA-434316 Reactome: R-HSA-444209 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative ELISA Names | Free Fatty Acid Receptor 1 ELISA kit G-Protein Coupled Receptor 40 ELISA kit FFAR1 ELISA kit GPR40 ELISA kit |
| output |
Information sourced from Uniprot.org
