Human Fc epsilon RI alpha protein (Recombinant) (His-Tag) (STJP019538)

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STJP019538
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Host: HEK293 Cells
Applications: SDS-PAGE/Bioactivity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Fc epsilon RI alpha-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity: Measured by its binding ability in a functional ELISA with Human IgE. The ED50 range ≤ 0.01 ug/ml.
Gene Symbol: FCER1A
Gene ID: 2205
Uniprot ID: FCERA_HUMAN
Immunogen Region: 26-205aa
Accession Number: NP_001374209.1
Immunogen: Human
Immunogen Sequence: VPQKPKVSLN PPWNRIFKGE NVTLTCNGNN FFEVSSTKWF HNGSLSEETN SSLNIVNAKF EDSGEYKCQH QQVNESEPVY LEVFSDWLLL QASAEVVMEG QPLFLRCHGW RNWDVYKVIY YKDGEALKYW YENHNISITN ATVEDSGTYY CTGKVWQLDY ESEPLNITVI KAPREKYWLQ
Tissue Specificity Expressed in eosinophils.
Function High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions.
Protein Name High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha
Fc-Epsilon Ri-Alpha
Fceri
Ige Fc Receptor Subunit Alpha
Database Links Reactome: R-HSA-2454202
Reactome: R-HSA-2730905
Reactome: R-HSA-2871796
Reactome: R-HSA-2871809
Reactome: R-HSA-2871837
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha protein
Fc-Epsilon Ri-Alpha protein
Fceri protein
Ige Fc Receptor Subunit Alpha protein
FCER1A protein
FCE1A protein

Information sourced from Uniprot.org

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