Human Fc epsilon RI alpha protein (Recombinant) (His-Tag) (STJP019538)
SPECIFICATIONS
HostHEK293 Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Fc epsilon RI alpha-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Bioactivity |
| Host | HEK293 Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Measured by its binding ability in a functional ELISA with Human IgE. The ED50 range ≤ 0.01 ug/ml. |
Target Information
| Gene Symbol | FCER1A |
| Gene ID | 2205 |
| Uniprot ID | FCERA_HUMAN |
| Accession Number | NP_001374209.1 |
| Immunogen | Human |
| Immunogen Region | 26-205aa |
| Immunogen Sequence | VPQKPKVSLN PPWNRIFKGE NVTLTCNGNN FFEVSSTKWF HNGSLSEETN SSLNIVNAKF EDSGEYKCQH QQVNESEPVY LEVFSDWLLL QASAEVVMEG QPLFLRCHGW RNWDVYKVIY YKDGEALKYW YENHNISITN ATVEDSGTYY CTGKVWQLDY ESEPLNITVI KAPREKYWLQ |
Additional Info
| Tissue Specificity | Expressed in eosinophils. |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit AlphaFc-Epsilon Ri-AlphaFceriIge Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha proteinFc-Epsilon Ri-Alpha proteinFceri proteinIge Fc Receptor Subunit Alpha proteinFCER1A proteinFCE1A protein |
Information sourced from Uniprot.org