Human FAHD1 protein (Recombinant) (His-Tag) (STJP017042)

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STJP017042
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human FAHD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: FAHD1
Gene ID: 81889
Uniprot ID: FAHD1_HUMAN
Immunogen Region: 1-224aa
Accession Number: NP_112485
Immunogen: Human
Immunogen Sequence: MGIMAASRPL SRFWEWGKNI VCVGRNYADH VREMRSAVLS EPVLFLKPST AYAPEGSPIL MPAYTRNLHH ELELGVVMGK RCRAVPEAAA MDYVGGYALC LDMTARDVQD ECKKKGLPWT LAKSFTASCP VSAFVPKEKI PDPHKLKLWL KVNGELRQEG ETSSMIFSIP YIISYVSKII TLEEGDIILT GTPKGVGPVK ENDEIE
Tissue Specificity Ubiquitous (at protein level).
Function Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Exhibits only a weak hydrolase activity on methylacetopyruvate and acetylacetone, and no activity toward acetoacetyl-CoA.
Protein Name Oxaloacetate Tautomerase Fahd1 - Mitochondrial
Acylpyruvase Fahd1
Fumarylacetoacetate Hydrolase Domain-Containing Protein 1
Fah Domain-Containing Protein 1
Oxaloacetate Decarboxylase
Oaa Decarboxylase
Odx
Yisk-Like Protein
Database Links Reactome: R-HSA-70268
Cellular Localisation Mitochondrion
Cytoplasm
Cytosol
Alternative Protein Names Oxaloacetate Tautomerase Fahd1 - Mitochondrial protein
Acylpyruvase Fahd1 protein
Fumarylacetoacetate Hydrolase Domain-Containing Protein 1 protein
Fah Domain-Containing Protein 1 protein
Oxaloacetate Decarboxylase protein
Oaa Decarboxylase protein
Odx protein
Yisk-Like Protein protein
FAHD1 protein
C16orf36 protein
YISKL protein

Information sourced from Uniprot.org

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