Human EFNB3 protein (Recombinant-Active) (C-His) (STJP012118)

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STJP012118-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human EFNB3-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: EFNB3
Gene ID: 1949
Uniprot ID: EFNB3_HUMAN
Immunogen Region: Leu28-Ser224
Immunogen: Homo sapiens (Human)
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for nipah virus and hendra virus.
Protein Name Ephrin-B3
Eph-Related Receptor Transmembrane Ligand Elk-L3
Eph-Related Receptor Tyrosine Kinase Ligand 8
Lerk-8
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928662
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Ephrin-B3 protein
Eph-Related Receptor Transmembrane Ligand Elk-L3 protein
Eph-Related Receptor Tyrosine Kinase Ligand 8 protein
Lerk-8 protein
EFNB3 protein
EPLG8 protein
LERK8 protein

Information sourced from Uniprot.org

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