Human EFNB3 protein (Recombinant-Active) (C-His) (STJP012118)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human EFNB3-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When recombinant human EphB3 is coated at 2 Mu g/mL, recombinant human EFNB3 binds with an apparent Kd < 0.4 nM. |
Target Information
| Gene Symbol | EFNB3 |
| Gene ID | 1949 |
| Uniprot ID | EFNB3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu28-Ser224 |
Additional Info
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. (Microbial infection) Acts as a receptor for nipah virus and hendra virus. |
| Protein Name | Ephrin-B3Eph-Related Receptor Transmembrane Ligand Elk-L3Eph-Related Receptor Tyrosine Kinase Ligand 8Lerk-8 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928662Reactome: R-HSA-3928664Reactome: R-HSA-3928665 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Ephrin-B3 proteinEph-Related Receptor Transmembrane Ligand Elk-L3 proteinEph-Related Receptor Tyrosine Kinase Ligand 8 proteinLerk-8 proteinEFNB3 proteinEPLG8 proteinLERK8 protein |
Information sourced from Uniprot.org