Function | Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex. |
Protein Name | Dual Specificity Protein Phosphatase 7Dual Specificity Protein Phosphatase Pyst2 |
Database Links | Reactome: R-HSA-112409Reactome: R-HSA-202670Reactome: R-HSA-5675221Reactome: R-HSA-9652817 |
Cellular Localisation | Cytoplasm |
Alternative Protein Names | Dual Specificity Protein Phosphatase 7 proteinDual Specificity Protein Phosphatase Pyst2 proteinDUSP7 proteinPYST2 protein |
Information sourced from Uniprot.org