Name: Human DTD2 protein (Recombinant) (His-Tag) (STJP018607)
SKU: STJP018607
Availability: InStock

Human DTD2 protein (Recombinant) (His-Tag) (STJP018607)

SKU:

STJP018607

$185.61 - $1,019.13

Short Description :	Recombinant-Human DTD2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:	SDS-PAGE
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration:	1 mg/mL
Formulation:	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DTD2
Gene ID:	112487
Uniprot ID:	DTD2_HUMAN
Accession Number:	NP_542395.1
Immunogen:	Human
Immunogen Region:	1-168aa
Immunogen Sequence:	MAEGSRI PQARALLQQC LHARLQIRPA DGDVAAQWVE VQRGLVIYVC FFKGADKELL PKMVNTLLNV KLSETENGKH VSILDLPGNI LIIPQATLGG RLKGRNMQYH SNSGKEEGFE LYSQFVTLCE KEVAANSKCA EARVVVEHGT YGNRQVLKLD TNGPFTHLIE F

Function	Deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS. Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site. Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation.
Protein Name	D-Aminoacyl-Trna Deacylase 2 Animalia-Specific Trna Deacylase Atd D-Tyrosyl-Trna(Tyr Deacylase 2 L-Alanyl-Trna Deacylase
Database Links
Cellular Localisation	Cytoplasm
Alternative Protein Names	D-Aminoacyl-Trna Deacylase 2 protein Animalia-Specific Trna Deacylase protein Atd protein D-Tyrosyl-Trna(Tyr Deacylase 2 protein L-Alanyl-Trna Deacylase protein DTD2 protein C14orf126 protein

Information sourced from Uniprot.org

Human DTD2 protein (Recombinant) (His-Tag) (STJP018607)

General Information

Model	Name	Host	Application
STJP019170	Human FGB protein (Recombinant) (His-Tag) (STJP019170)	E.coli	SDS-PAGE
STJP019149	Human PYCR2 protein (Recombinant) (His-Tag) (STJP019149)	E.coli	SDS-PAGE
STJP019163	Human ALDH6A1 protein (Recombinant) (His-Tag) (STJP019163)	E.coli	SDS-PAGE
STJP019189	Human UBE2Q2 protein (Recombinant) (His-Tag) (STJP019189)	E.coli	SDS-PAGE
STJP019134	Human ETNK2 protein (Recombinant) (His-Tag) (STJP019134)	E.coli	SDS-PAGE