| Host: | HEK293 Cells |
| Applications: | SDS-PAGE/Bioactivity |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human DSPG3-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity: | Measured by the ability of the immobilized protein to support the adhesion of Saos‑2 human osteosarcoma cells. When cells are added to human DSPG3 1.25 ug/ml and human fibronectin 0.5 ug/ml coated plates. This effect is more to 60%. |
| Gene Symbol: | EPYC |
| Gene ID: | 1833 |
| Uniprot ID: | EPYC_HUMAN |
| Immunogen Region: | 20-322aa |
| Accession Number: | NP_004941.2 |
| Immunogen: | Human |
| Immunogen Sequence: | APTLESINYD SETYDATLED LDNLYNYENI PVDKVEIEIA TVMPSGNREL LTPPPQPEKA QEEEEEEEST PRLIDGSSPQ EPEFTGVLGP HTNEDFPTCL LCTCISTTVY CDDHELDAIP PLPKNTAYFY SRFNRIKKIN KNDFASLSDL KRIDLTSNLI SEIDEDAFRK LPQLRELVLR DNKIRQLPEL PTTLTFIDIS NNRLGRKGIK QEAFKDMYDL HHLYLTDN |
| Tissue Specificity | Cartilage, ligament, and placenta. |
| Post Translational Modifications | The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64. |
| Function | May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization. |
| Protein Name | EpiphycanDermatan Sulfate Proteoglycan 3Proteoglycan-LbPg-LbSmall Chondroitin/Dermatan Sulfate Proteoglycan |
| Database Links | |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Epiphycan proteinDermatan Sulfate Proteoglycan 3 proteinProteoglycan-Lb proteinPg-Lb proteinSmall Chondroitin/Dermatan Sulfate Proteoglycan proteinEPYC proteinDSPG3 proteinPGLB proteinSLRR3B protein |
Information sourced from Uniprot.org