| Function | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. |
| Protein Name | Protein Dpy-30 HomologDpy-30-Like ProteinDpy-30l |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-9772755Reactome: R-HSA-9818564Reactome: R-HSA-9841922 |
| Cellular Localisation | NucleusGolgi ApparatusTrans-Golgi NetworkAssociated With Chromatin At Regions Enriched In Histone H3 Trimethylated At 'Lys-4Highly Enriched In Gene Promoter Regions And 5' UtrsBut Not In Downstream Regions Of Genes Or 3' Utrs |
| Alternative Protein Names | Protein Dpy-30 Homolog proteinDpy-30-Like Protein proteinDpy-30l proteinDPY30 protein |
Information sourced from Uniprot.org