Human DNA polymerase lambda/POLL protein (Recombinant) (His-Tag) (STJP017380)

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STJP017380
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Dpolymerase lambda/POLL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% Glycerol, 0.1M NaCl
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: POLL
Gene ID: 27343
Uniprot ID: DPOLL_HUMAN
Immunogen Region: 1-300aa
Accession Number: AAH03548
Immunogen: Human
Immunogen Sequence: MLMHHQKYLQ RFLGGKREKK QKEACSIPGI GKRMAEKIIE ILESGHLRKL DHISESVPVL ELFSNIWGAG TKTAQMWYQQ GFRSLEDIRS QASLTTQQAI GLKHYSDFLE RMPREEATEI EQTVQKAAQA FNSGLLCVAC GSYRRGKATC GDVDVLITHP DGRSHRGIFS RLLDSLRQEG FLTDDLVSQE ENGQQQKYLG VCRLPG
Tissue Specificity Expressed in a number of tissues. Abundant in testis.
Function DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
Protein Name Dna Polymerase Lambda
Pol Lambda
Dna Polymerase Beta-2
Pol Beta2
Dna Polymerase Kappa
Database Links Reactome: R-HSA-5693571
Cellular Localisation Nucleus
Chromosome
Accumulates At Sites Of Dna Damage
Alternative Protein Names Dna Polymerase Lambda protein
Pol Lambda protein
Dna Polymerase Beta-2 protein
Pol Beta2 protein
Dna Polymerase Kappa protein
POLL protein

Information sourced from Uniprot.org