Human DKK4 protein (Recombinant-Active) (C-10*His) (STJP012308)

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STJP012308-100
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Covered by St John's Laboratory Guarantee

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human DKK4-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: DKK4
Gene ID: 27121
Uniprot ID: DKK4_HUMAN
Immunogen Region: Leu19-Leu224
Immunogen: Homo sapiens (Human)
Post Translational Modifications Appears to be not glycosylated. Can be proteolytically processed by a furin-like protease.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Protein Name Dickkopf-Related Protein 4
Dickkopf-4
Dkk-4
Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Secreted
Alternative Protein Names Dickkopf-Related Protein 4 protein
Dickkopf-4 protein
Dkk-4 protein
Hdkk-4 Cleaved Into - Dickkopf-Related Protein 4 Short Form protein
DKK4 protein

Information sourced from Uniprot.org

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