Human DKK3 protein (Recombinant-Active) (C-His) (STJP012306)

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STJP012306-100
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Covered by St John's Laboratory Guarantee

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human DKK3-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: DKK3
Gene ID: 27122
Uniprot ID: DKK3_HUMAN
Immunogen Region: Ala22-Ile350
Immunogen: Homo sapiens (Human)
Post Translational Modifications N- and O-glycosylated.
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Protein Name Dickkopf-Related Protein 3
Dickkopf-3
Dkk-3
Hdkk-3
Cellular Localisation Secreted
Alternative Protein Names Dickkopf-Related Protein 3 protein
Dickkopf-3 protein
Dkk-3 protein
Hdkk-3 protein
DKK3 protein
REIC protein
UNQ258 protein
PRO295 protein

Information sourced from Uniprot.org

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