Human DHX16 protein (Recombinant) (N-His) (STJP010692)

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STJP010692
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DHX16-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DHX16
Gene ID: 8449
Uniprot ID: DHX16_HUMAN
Immunogen Region: Glu364-Glu746
Immunogen: Homo sapiens (Human)
Function Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Plays also a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses.
Protein Name Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16
Atp-Dependent Rna Helicase #3
Deah-Box Protein 16
Database Links Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleoplasm
Cytoplasm
Alternative Protein Names Pre-Mrna-Splicing Factor Atp-Dependent Rna Helicase Dhx16 protein
Atp-Dependent Rna Helicase #3 protein
Deah-Box Protein 16 protein
DHX16 protein
DBP2 protein
DDX16 protein
KIAA0577 protein
PRP2 protein

Information sourced from Uniprot.org

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