SDS-PAGE of recombinant human DCPS protein under reducing conditions with Coomassie blue staining

Human DCPS protein (Recombinant) (His-Tag) (STJP017292)

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STJP017292
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Short Description :Recombinant-Human DCPS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:DCPS
Gene ID:28960
Uniprot ID:DCPS_HUMAN
Accession Number:NP_054745
Immunogen:Human
Immunogen Region:1-337aa
Immunogen Sequence: MADAAPQLGK RKRELDVEEA HAASTEEKEA GVGNGTCAPV RLPFSGFRLQ KVLRESARDK IIFLHGKVNE ASGDGDGEDA VVILEKTPFQ VEQVAQLLTG SPELQLQFSN DIYSTYHLFP PRQLNDVKTT VVYPATEKHL QKYLRQDLRL IRETGDDYRN ITLPHLESQS LSIQWVYNIL DKKAEADRIV FENPDPSDGF VLIPDL
Tissue Specificity Detected in liver, brain, kidney, testis and prostate.
Function Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway.m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death.
Protein Name M7gpppx Diphosphatase
Dcs-1
Decapping Scavenger Enzyme
Hint-Related 7megmp-Directed Hydrolase
Histidine Triad Nucleotide-Binding Protein 5
Histidine Triad Protein Member 5
Hint-5
Scavenger Mrna-Decapping Enzyme Dcps
Database Links Reactome: R-HSA-429958
Cellular Localisation Cytoplasm
Nucleus
Predominantly Localized In The Nucleus
Nucleocytoplasmic Shuttling Protein That Can Transiently Enter The Cytoplasm In Mammalian Cells In A Xpo1/Crm1-Dependent Manner
Alternative Protein Names M7gpppx Diphosphatase protein
Dcs-1 protein
Decapping Scavenger Enzyme protein
Hint-Related 7megmp-Directed Hydrolase protein
Histidine Triad Nucleotide-Binding Protein 5 protein
Histidine Triad Protein Member 5 protein
Hint-5 protein
Scavenger Mrna-Decapping Enzyme Dcps protein
DCPS protein
DCS1 protein
HINT5 protein
HSPC015 protein

Information sourced from Uniprot.org

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