Human DAP protein (Recombinant) (His-Tag) (STJP018874)

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STJP018874
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Short Description :Recombinant-Human DAP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:DAP
Gene ID:1611
Uniprot ID:DAP1_HUMAN
Accession Number:NP_004385
Immunogen:Human
Immunogen Region:1-102aa
Immunogen Sequence:MSSPPEG KLETKAGHPP AVKAGGMRIV QKHPHTGDTK EEKDKDDQEW ESPSPPKPTV FISGVIARGD KDFPPAAAQV AHQKPHASMD KHPSPRTQHI QQPRK
Post Translational Modifications Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
Function Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo. Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
Protein Name Death-Associated Protein 1
Dap-1
Database Links
Cellular Localisation
Alternative Protein Names Death-Associated Protein 1 protein
Dap-1 protein
DAP protein
DAP1 protein

Information sourced from Uniprot.org

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