Human DAP protein (Recombinant) (His-Tag) (STJP018874)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DAP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DAP |
| Gene ID | 1611 |
| Uniprot ID | DAP1_HUMAN |
| Accession Number | NP_004385 |
| Immunogen | Human |
| Immunogen Region | 1-102aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. |
| Function | Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo. Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death. |
| Protein Name | Death-Associated Protein 1Dap-1 |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | Death-Associated Protein 1 proteinDap-1 proteinDAP proteinDAP1 protein |
Information sourced from Uniprot.org