Human CYP2E1 protein (Recombinant) (His-Tag) (STJP019080)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CYP2E1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYP2E1 |
| Gene ID | 1571 |
| Uniprot ID | CP2E1_HUMAN |
| Accession Number | NP_000764.1 |
| Immunogen | Human |
| Immunogen Region | 29-493aa |
| Immunogen Sequence |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics (Probable). |
| Protein Name | Cytochrome P450 2e14-Nitrophenol 2-HydroxylaseCypiie1Cytochrome P450-J |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-211999Reactome: R-HSA-9027307Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome MembraneMitochondrion Inner MembranePost-Translationally Targeted To MitochondriaTomm70 Is Required For The Translocation Across The Mitochondrial Outer MembraneAfter Translocation Into The MatrixAssociates With The Inner Membrane As A Membrane Extrinsic Protein |
| Alternative Protein Names | Cytochrome P450 2e1 protein4-Nitrophenol 2-Hydroxylase proteinCypiie1 proteinCytochrome P450-J proteinCYP2E1 proteinCYP2E protein |
Information sourced from Uniprot.org