SDS-PAGE gel of recombinant human CYP2E1 protein under reducing conditions stained with Coomassie blue

Human CYP2E1 protein (Recombinant) (His-Tag) (STJP019080)

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STJP019080
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Short Description :Recombinant-Human CYP2E1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:CYP2E1
Gene ID:1571
Uniprot ID:CP2E1_HUMAN
Accession Number:NP_000764.1
Immunogen:Human
Immunogen Region:29-493aa
Immunogen Sequence:SWNLPPG PFPLPIIGNL FQLELKNIPK SFTRLAQRFG PVFTLYVGSQ RMVVMHGYKA VKEALLDYKD EFSGRGDLPA FHAHRDRGII FNNGPTWKDI RRFSLTTLRN YGMGKQGNES RIQREAHFLL EALRKTQGQP FDPTFLIGCA PCNVIADILF RKHFDYNDEK FLRLMYLFNE NFHLLSTPWL QLYNNFPSFL HYLPGS
Function A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics (Probable).
Protein Name Cytochrome P450 2e1
4-Nitrophenol 2-Hydroxylase
Cypiie1
Cytochrome P450-J
Database Links Reactome: R-HSA-211981
Reactome: R-HSA-211999
Reactome: R-HSA-9027307
Reactome: R-HSA-9749641
Reactome: R-HSA-9753281
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Microsome Membrane
Mitochondrion Inner Membrane
Post-Translationally Targeted To Mitochondria
Tomm70 Is Required For The Translocation Across The Mitochondrial Outer Membrane
After Translocation Into The Matrix
Associates With The Inner Membrane As A Membrane Extrinsic Protein
Alternative Protein Names Cytochrome P450 2e1 protein
4-Nitrophenol 2-Hydroxylase protein
Cypiie1 protein
Cytochrome P450-J protein
CYP2E1 protein
CYP2E protein

Information sourced from Uniprot.org

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