Human CYP27B1 protein (Recombinant) (N-His) (STJP006543)

SKU:
STJP006543
£328.50 - £1,437.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CYP27B1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CYP27B1
Gene ID: 1594
Uniprot ID: CP27B_HUMAN
Immunogen Region: Asp256-Arg508
Immunogen: Homo sapiens (Human)
Function A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway. Converts 24R,25-dihydroxyvitamin D3/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR/adrenodoxin reductase and FDX1/adrenodoxin.
Protein Name 25-Hydroxyvitamin D-1 Alpha Hydroxylase - Mitochondrial
25-Ohd-1 Alpha-Hydroxylase
25-Hydroxyvitamin D(3 1-Alpha-Hydroxylase
Vd3 1a Hydroxylase
Calcidiol 1-Monooxygenase
Cytochrome P450 Subfamily Xxviib Polypeptide 1
Cytochrome P450c1 Alpha
Cytochrome P450vd1-Alpha
Cytochrome P450 27b1
Database Links Reactome: R-HSA-196791
Reactome: R-HSA-211916
Reactome: R-HSA-5579014
Cellular Localisation Mitochondrion Membrane
Alternative Protein Names 25-Hydroxyvitamin D-1 Alpha Hydroxylase - Mitochondrial protein
25-Ohd-1 Alpha-Hydroxylase protein
25-Hydroxyvitamin D(3 1-Alpha-Hydroxylase protein
Vd3 1a Hydroxylase protein
Calcidiol 1-Monooxygenase protein
Cytochrome P450 Subfamily Xxviib Polypeptide 1 protein
Cytochrome P450c1 Alpha protein
Cytochrome P450vd1-Alpha protein
Cytochrome P450 27b1 protein
CYP27B1 protein
CYP1ALPHA protein
CYP27B protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP005172 Human COL10A1, N-His protein (Recombinant) (N-His) (STJP005172) E. coli
STJP004723 Human WAS protein (Recombinant) (N-His) (STJP004723) E. coli
STJP011678 Human FSTL1 protein (Recombinant) (N-His) (STJP011678) E. coli
STJP003644 Human ALDOA protein (Recombinant) (N-His) (STJP003644) E. coli
STJP003667 Human KRT1 protein (Recombinant) (N-His) (STJP003667) E. coli

Related Products

!