| Post Translational Modifications | Phosphorylated by PKC/PRKCA. |
| Function | Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization.the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling. Isoform 2: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. |
| Protein Name | Cysteine And Glycine-Rich Protein 3Cardiac Lim ProteinCysteine-Rich Protein 3Crp3Lim Domain Protein - CardiacMuscle Lim Protein |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMyofibrilSarcomereZ LineNucleocytoplasmic Shuttling ProteinMainly CytoplasmicIn The Z LineFound Associated With Glrx3Isoform 2: Cytoplasm |
| Alternative Protein Names | Cysteine And Glycine-Rich Protein 3 proteinCardiac Lim Protein proteinCysteine-Rich Protein 3 proteinCrp3 proteinLim Domain Protein - Cardiac proteinMuscle Lim Protein proteinCSRP3 proteinCLP proteinMLP protein |
Information sourced from Uniprot.org
