| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CSF-1/M-CSF-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
1.Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 at 1 Mu g/mL (100 Mu L/well) can bind Human CSF1R with a linear range of 0.01-7.8 ng/mL.2.Measured in a cell proliferation assay using M-NFS-60 mouse myelogenous leukemia |
| Gene Symbol: |
CSF1 |
| Gene ID: |
1435 |
| Uniprot ID: |
CSF1_HUMAN |
| Immunogen Region: |
Glu33-Arg255 |
| Immunogen: |
Recombinant Human CSF-1/M-CSF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu33-Arg255) of human M-CSF/CSF-1 (Accession #NP_000748.3) fused with a 6×His tag at the C-terminus. |
| Function | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| Protein Name | Macrophage Colony-Stimulating Factor 1Csf-1M-CsfMcsfLanimostimProteoglycan Macrophage Colony-Stimulating FactorPg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-449836Reactome: R-HSA-6783783Reactome: R-HSA-8957275Reactome: R-HSA-9680350 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinProcessed Macrophage Colony-Stimulating Factor 1: SecretedExtracellular Space |
| Alternative Protein Names | Macrophage Colony-Stimulating Factor 1 proteinCsf-1 proteinM-Csf proteinMcsf proteinLanimostim proteinProteoglycan Macrophage Colony-Stimulating Factor proteinPg-M-Csf Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 - Macrophage Colony-Stimulating Factor 1 43 Kda Subunit proteinCSF1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
