Human COQ9 protein (Recombinant) (His-Tag) (STJP019127)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human COQ9-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COQ9 |
| Gene ID | 57017 |
| Uniprot ID | COQ9_HUMAN |
| Accession Number | NP_064708 |
| Immunogen | Human |
| Immunogen Region | 45-318aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSRSSDEQK QQPPNSFSQQ HSETQGAEKP DPESSHSPPR YTDQGGEEEE DYESEEQLQH RILTAALEFV PAHGWTAEAI AEGAQSLGLS SAAASMFGKD GSELILHFVT QCNTRLTRVL EEEQKLVQLG QAEKRKTDQF LRDAVETRLR MLIPYIEHWP RALSILMLPH NIPSSLSLLT SMVDDMWHYA GDQSTDFNWY TRRAMLAA |
Additional Info
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. |
| Protein Name | Ubiquinone Biosynthesis Protein Coq9 - Mitochondrial |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | MitochondrionAssociates With Cardiolipin-Rich Membranes Which Leads To The Lipid Bilayer Deformation And Then Accessing To Membrane-Bound Lipids |
| Alternative Protein Names | Ubiquinone Biosynthesis Protein Coq9 - Mitochondrial proteinCOQ9 proteinC16orf49 proteinHSPC326 proteinPSEC0129 protein |
Information sourced from Uniprot.org