SDS-PAGE gel showing recombinant human Complexin-1 protein 3ug under reducing conditions with Coomassie blue stain

Human Complexin-1 protein (Recombinant) (His-Tag) (STJP019593)

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STJP019593
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Short Description :Recombinant-Human Complexin-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol:CPLX1
Gene ID:10815
Uniprot ID:CPLX1_HUMAN
Accession Number:NP_006642
Immunogen:Human
Immunogen Region:1-134aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK
Tissue Specificity Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
Function Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Protein Name Complexin-1
Complexin I
Cpx I
Synaphin-2
Database Links Reactome: R-HSA-181429
Reactome: R-HSA-181430
Reactome: R-HSA-210500
Reactome: R-HSA-212676
Reactome: R-HSA-264642
Reactome: R-HSA-888590
Cellular Localisation Cytoplasm
Cytosol
Perikaryon
Presynapse
Enriched At Synaptic-Releasing Sites In Mature Neurons
Alternative Protein Names Complexin-1 protein
Complexin I protein
Cpx I protein
Synaphin-2 protein
CPLX1 protein

Information sourced from Uniprot.org

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