| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Gly-Arg-ThioBenzyl ester (Z-GR-SBzl) , in the presence of 5, 5 Dithio-bis (2-nitrobenzoic acid) (DTNB).The specific activity is >2828 pmol/min/Mu g, as measured unde |
| Gene Symbol: | C1R |
| Gene ID: | 715 |
| Uniprot ID: | C1R_HUMAN |
| Immunogen Region: | Met1-Asp705 |
| Immunogen: | Recombinant Human Complement C1r subcomponent Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Asp705) of human Complement C1r subcomponent (Accession #NP_001724.3) fused with a 6×His tag at t |
| Immunogen Sequence: | MWLLYLLVPALFCRAGGSIP IPQKLFGEVTSPLFPKPYPN NFETTTVITVPTGYRVKLVF QQFDLEPSEGCFYDYVKISA DKKSLGRFCGQLGSPLGNPP GKKEFMSQGNKMLLTFHTDF SNEENGTIMFYKGFLAYYQA VDLDECASRSKLGEEDPQPQ CQHLCHNYVGGYFCSCRPGY ELQEDRHSCQAECSSELYTE ASGYISSLEYPRSYPPDLRC NYSIRVERGLTLHLKFLEP |
| Post Translational Modifications | The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. |
| Protein Name | Complement C1r SubcomponentComplement Component 1 Subcomponent R Cleaved Into - Complement C1r Subcomponent Heavy Chain - Complement C1r Subcomponent Light Chain |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Complement C1r Subcomponent proteinComplement Component 1 Subcomponent R Cleaved Into - Complement C1r Subcomponent Heavy Chain - Complement C1r Subcomponent Light Chain proteinC1R protein |
Information sourced from Uniprot.org
