| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CNTFR at 3 Mu g/mL (100 Mu L/well) can bind Recombinant Human CNTF with a linear range of 0.078-6.3 Mu g/mL. |
| Gene Symbol: | CNTFR |
| Gene ID: | 1271 |
| Uniprot ID: | CNTFR_HUMAN |
| Immunogen Region: | Gln 23-Pro 346 |
| Immunogen: | Recombinant Human CNTFR-alpha Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln 23-Pro 346 ) of human CNTF R alpha (Accession #NP_001833.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | QRHSPQEAPHVQYERLGSDV TLPCGTANWDAAVTWRVNGT DLAPDLLNGSQLVLHGLELG HSGLYACFHRDSWHLRHQVL LHVGLPPREPVLSCRSNTYP KGFYCSWHLPTPTYIPNTFN VTVLHGSKIMVCEKDPALKN RCHIRYMHLFSTIKYKVSIS VSNALGHNATAITFDEFTIV KPDPPENVVARPVPSNPRRL EVTWQTPSTWPDPESFPLKF FLRYRPLILDQWQHVELSD |
| Tissue Specificity | Nervous system and skeletal muscle. |
| Function | Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1. |
| Protein Name | Ciliary Neurotrophic Factor Receptor Subunit AlphaCntf Receptor Subunit AlphaCntfr-Alpha |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Ciliary Neurotrophic Factor Receptor Subunit Alpha proteinCntf Receptor Subunit Alpha proteinCntfr-Alpha proteinCNTFR protein |
Information sourced from Uniprot.org