Human CNP protein (Recombinant) (His-Tag) (STJP018311)

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STJP018311
£134.50 - £285.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CNP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: NPPC
Gene ID: 4880
Uniprot ID: ANFC_HUMAN
Immunogen Region: 24-126aa
Accession Number: NP_077720.1
Immunogen: Human
Immunogen Sequence: KPGAPPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS MSGLGC
Tissue Specificity CNP-22: In the kidney, predominantly expressed in the distal tubular cells (at protein level).
Post Translational Modifications CNP-22: Degraded by IDE (in vitro).
Function CNP-22: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3.
Protein Name C-Type Natriuretic Peptide Cleaved Into - Cnp-22 - Cnp-29 - Cnp-53
Database Links Reactome: R-HSA-5578768
Cellular Localisation Secreted
Alternative Protein Names C-Type Natriuretic Peptide Cleaved Into - Cnp-22 - Cnp-29 - Cnp-53 protein
NPPC protein
CNP2 protein

Information sourced from Uniprot.org

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