Human CLL-1/MICL/CD371 protein (Recombinant) (C-His) (STJP001098)

SKU:

STJP001098

£114.50 - £491.50

Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human CLL-1/MICL/CD371-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.

Formulation:

Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.

Gene Symbol:	CLEC12A
Gene ID:	160364
Uniprot ID:	CL12A_HUMAN
Immunogen:	Recombinant Human CLL-1/MICL/CD371 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His75-Ala275) of human CLEC12A (Accession #NP_001193939.1) fused with a 6×His tag at the C-terminus.

Tissue Specificity	Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
Post Translational Modifications	Highly N-glycosylated. Glycosylation varies between cell types.
Function	Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Protein Name	C-Type Lectin Domain Family 12 Member A C-Type Lectin-Like Molecule 1 Cll-1 Dendritic Cell-Associated Lectin 2 Dcal-2 Myeloid Inhibitory C-Type Lectin-Like Receptor Micl Cd Antigen Cd371
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Ligand Binding Leads To Internalization
Alternative Protein Names	C-Type Lectin Domain Family 12 Member A protein C-Type Lectin-Like Molecule 1 protein Cll-1 protein Dendritic Cell-Associated Lectin 2 protein Dcal-2 protein Myeloid Inhibitory C-Type Lectin-Like Receptor protein Micl protein Cd Antigen Cd371 protein CLEC12A protein CLL1 protein DCAL2 protein MICL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance