Human CLIC2 protein (Recombinant) (N-His) (STJP014260)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLIC2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 20% Glycerol, pH 8.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CLIC2 |
| Gene ID | 1193 |
| Uniprot ID | CLIC2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser247 |
Additional Info
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. |
| Protein Name | Chloride Intracellular Channel Protein 2Glutaredoxin-Like Oxidoreductase Clic2Glutaredoxin-Like Peroxidase Clic2Xap121 |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | CytoplasmMembraneSingle-Pass Membrane ProteinExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane Domain |
| Alternative Protein Names | Chloride Intracellular Channel Protein 2 proteinGlutaredoxin-Like Oxidoreductase Clic2 proteinGlutaredoxin-Like Peroxidase Clic2 proteinXap121 proteinCLIC2 protein |
Information sourced from Uniprot.org