• Human CLEC7A/Dectin-1/CD369 protein (Recombinant) (N-raFc) (STJP001517)

Human CLEC7A/Dectin-1/CD369 protein (Recombinant) (N-raFc) (STJP001517)

SKU:
STJP001517

£76.50 - £231.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CLEC7A/Dectin-1/CD369-N-raFc protein was developed from hek293 cells and has a target region of N-raFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: CLEC7A
Gene ID: 64581
Uniprot ID: CLC7A_HUMAN
Immunogen: Recombinant Human CLEC7A/Dectin-1/CD369 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr66-Met247) of human CLEC7A/Dectin-1/CD369 (Accession #NP_922938.1) fused with a raFc tag at the N-terminu
Post Translational Modifications Phosphorylated on tyrosine residues in response to beta-glucan binding.
Function Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans.
Protein Name C-Type Lectin Domain Family 7 Member A
Beta-Glucan Receptor
C-Type Lectin Superfamily Member 12
Dendritic Cell-Associated C-Type Lectin 1
Dc-Associated C-Type Lectin 1
Dectin-1
Cd Antigen Cd369
Database Links Reactome: R-HSA-5607764
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Isoform 5: Cytoplasm
Isoform 6: Cytoplasm
Isoform 7: Cytoplasm
Alternative Protein Names C-Type Lectin Domain Family 7 Member A protein
Beta-Glucan Receptor protein
C-Type Lectin Superfamily Member 12 protein
Dendritic Cell-Associated C-Type Lectin 1 protein
Dc-Associated C-Type Lectin 1 protein
Dectin-1 protein
Cd Antigen Cd369 protein
CLEC7A protein
BGR protein
CLECSF12 protein
DECTIN1 protein
UNQ539 protein
PRO1082 protein

Information sourced from Uniprot.org

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