Human CLEC5A/MDL1 protein (Recombinant) (C-His) (STJP009265)

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STJP009265
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CLEC5A/MDL1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CLEC5A
Gene ID: 23601
Uniprot ID: CLC5A_HUMAN
Immunogen Region: Pro28-Lys188
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. Contains sialic acid residues.
Function Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release.
Protein Name C-Type Lectin Domain Family 5 Member A
C-Type Lectin Superfamily Member 5
Myeloid Dap12-Associating Lectin 1
Mdl-1
Database Links Reactome: R-HSA-2172127
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names C-Type Lectin Domain Family 5 Member A protein
C-Type Lectin Superfamily Member 5 protein
Myeloid Dap12-Associating Lectin 1 protein
Mdl-1 protein
CLEC5A protein
CLECSF5 protein
MDL1 protein

Information sourced from Uniprot.org

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