| Tissue Specificity | Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. |
| Post Translational Modifications | Glycosylated. |
| Function | Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. |
| Protein Name | Chitinase-3-Like Protein 139 Kda Synovial ProteinCartilage Glycoprotein 39Cgp-39Gp-39Hcgp-39Ykl-40 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCytoplasmPerinuclear RegionEndoplasmic Reticulum |
| Alternative Protein Names | Chitinase-3-Like Protein 1 protein39 Kda Synovial Protein proteinCartilage Glycoprotein 39 proteinCgp-39 proteinGp-39 proteinHcgp-39 proteinYkl-40 proteinCHI3L1 protein |
Information sourced from Uniprot.org
