| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to cleave 4-Methylumbelliferyl-beta-D-N, N NA, N”-triacetylchitotriose (4-MU-TACT). The specific activity is >43571 pmol/min/Mu g. |
| Gene Symbol: | CHIT1 |
| Gene ID: | 1118 |
| Uniprot ID: | CHIT1_HUMAN |
| Immunogen: | Recombinant Human Chitinase-1/CHIT1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala22-Asn466) of human CHIT1 (Accession #NP_003456) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | AKLVCYFTNWAQYRQGEARF LPKDLDPSLCTHLIYAFAGM TNHQLSTTEWNDETLYQEFN GLKKMNPKLKTLLAIGGWNF STQKFTDMVATANNRQTFVN SAIRFLRKYSFDGLDLDWEY PGSQGSPAVDKERFTTLVQD LANAFQQEAQTSGKERLLLS AAVPAGQTYVDAGYEVDKIA QNLDFVNLMAYDFHGSWEKV TGHNSPLYKRQEESGAAASL NVDAAVQQWLQKGTPASKL |
| Tissue Specificity | Detected in spleen. Secreted by cultured macrophages. |
| Function | Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. |
| Protein Name | Chitotriosidase-1 Chitinase-1 |
| Database Links | Reactome: R-HSA-189085 Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted Lysosome A Small Proportion Is Lysosomal |
| Alternative Protein Names | Chitotriosidase-1 protein Chitinase-1 protein CHIT1 protein |
Information sourced from Uniprot.org
