| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CES3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | CES3 |
| Gene ID: | 23491 |
| Uniprot ID: | EST3_HUMAN |
| Immunogen Region: | Ser398-Gln568 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | N-glycosylated. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-4-(1-piperidino)-1-piperidino-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. |
| Protein Name | Carboxylesterase 3Liver Carboxylesterase 31 Homolog |
| Database Links | Reactome: R-HSA-211945Reactome: R-HSA-8964038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Protein Names | Carboxylesterase 3 proteinLiver Carboxylesterase 31 Homolog proteinCES3 proteinUNQ869 proteinPRO1887 protein |
Information sourced from Uniprot.org