| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CEACAM6 at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Human CEACAM8 with a linear range of 0.1-0.4 Mu g/mL. |
| Gene Symbol: |
CEACAM6 |
| Gene ID: |
4680 |
| Uniprot ID: |
CEAM6_HUMAN |
| Immunogen Region: |
Lys35-Gly320 |
| Immunogen: |
Recombinant Human CEACAM6/CD66c Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys35-Gly320) of human CEACAM6 (Accession #NP_002474.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
KLTIESTPFNVAEGKEVLLL AHNLPQNRIGYSWYKGERVD GNSLIVGYVIGTQQATPGPA YSGRETIYPNASLLIQNVTQ NDTGFYTLQVIKSDLVNEEA TGQFHVYPELPKPSISSNNS NPVEDKDAVAFTCEPEVQNT TYLWWVNGQSLPVSPRLQLS NGNMTLTLLSVKRNDAGSYE CEIQNPASANRSDPVTLNVL YGPDGPTISPSKANYRPGEN LNLSCHAASNPPAQYSWFI |
| Post Translational Modifications | Glycosylated. |
| Function | Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. Plays a role in cell migration and cell adhesion to endothelial cells. |
| Protein Name | Cell Adhesion Molecule Ceacam6Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6Cea Cell Adhesion Molecule 6Non-Specific Crossreacting AntigenNormal Cross-Reacting AntigenCd Antigen Cd66c |
| Database Links | Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneCell SurfaceLocalized To The Apical Glycocalyx Surface |
| Alternative Protein Names | Cell Adhesion Molecule Ceacam6 proteinCarcinoembryonic Antigen-Related Cell Adhesion Molecule 6 proteinCea Cell Adhesion Molecule 6 proteinNon-Specific Crossreacting Antigen proteinNormal Cross-Reacting Antigen proteinCd Antigen Cd66c proteinCEACAM6 proteinNCA protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
