Human CDK2AP2 protein (Recombinant) (His-Tag) (STJP017975)

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STJP017975
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CDK2AP2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 2mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDK2AP2
Gene ID: 10263
Uniprot ID: CDKA2_HUMAN
Immunogen Region: 1-126aa
Accession Number: NP_005842
Immunogen: Human
Immunogen Sequence: MSYKPIA PAPSSTPGSS TPGPGTPVPT GSVPSPSGSV PGAGAPFRPL FNDFGPPSMG YVQAMKPPGA QGSQSTYTDL LSVIEEMGKE IRPTYAGSKS AMERLKRGII HARALVRECL AETERNART
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylated by MAPK1 and CDK2.
Function Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation.represses CDK2 activation by inhibiting its interaction with cyclin E and A. Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes.
Protein Name Cyclin-Dependent Kinase 2-Associated Protein 2
Cdk2-Associated Protein 2
Doc-1-Related Protein
Doc-1r
Database Links
Cellular Localisation Cytoplasm
Nucleus
Accumulates In Immature Oocytes In The Nucleus
During The First Meiotic Division
Accumulates In The Cytoplasm And Localizes In Dots In The Vicinity Of The Chromosomes In A Region Enriched In Microtubules
Alternative Protein Names Cyclin-Dependent Kinase 2-Associated Protein 2 protein
Cdk2-Associated Protein 2 protein
Doc-1-Related Protein protein
Doc-1r protein
CDK2AP2 protein
DOC1R protein

Information sourced from Uniprot.org

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