Human CD85d/LILRB2/ILT4 protein (Recombinant-Active) (C-His) (STJP012202)

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STJP012202-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human CD85d/LILRB2/ILT4-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: LILRB2
Gene ID: 10288
Uniprot ID: LIRB2_HUMAN
Immunogen Region: Gln22-Leu458
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2
Lir-2
Leukocyte Immunoglobulin-Like Receptor 2
Cd85 Antigen-Like Family Member D
Immunoglobulin-Like Transcript 4
Ilt-4
Monocyte/Macrophage Immunoglobulin-Like Receptor 10
Mir-10
Cd Antigen Cd85d
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 protein
Lir-2 protein
Leukocyte Immunoglobulin-Like Receptor 2 protein
Cd85 Antigen-Like Family Member D protein
Immunoglobulin-Like Transcript 4 protein
Ilt-4 protein
Monocyte/Macrophage Immunoglobulin-Like Receptor 10 protein
Mir-10 protein
Cd Antigen Cd85d protein
LILRB2 protein
ILT4 protein
LIR2 protein
MIR10 protein

Information sourced from Uniprot.org

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