| Tissue Specificity | Expressed in myeloid antigen presenting cells in lymph nodes and skin (at protein level). Expressed in dermal dendritic cells (at protein level). |
| Function | C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides. Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions. Acts as an endocytic pattern recognition receptor involved in antitumor immunity. During tumorigenesis, recognizes Tn antigens and its sialylated forms Neu5Ac-Tn and Neu5Gc-Tn expressed on tumor cell mucins. On immature dendritic cells, can internalize Tn-terminated immunogens and target them to endolysosomal compartment for MHC class I and II antigen presentation to CD8-positive and CD4-positive T cells, respectively. |
| Protein Name | C-Type Lectin Domain Family 10 Member AC-Type Lectin Superfamily Member 14Dc-Asialoglycoprotein ReceptorDc-AsgprMacrophage Galactose-Type LectinMglMacrophage Lectin 2Cd Antigen Cd301 |
| Database Links | Reactome: R-HSA-5621480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEarly Endosome MembraneLysosome MembraneRecycles Between The Plasma Membrane And The Endolysosomal CompartmentUpon Antigen BindingInternalizes Via Endocytosis And Then Dissociates From Antigen At Acidic Ph Characteristic Of Endolysosomal Vesicles |
| Alternative Protein Names | C-Type Lectin Domain Family 10 Member A proteinC-Type Lectin Superfamily Member 14 proteinDc-Asialoglycoprotein Receptor proteinDc-Asgpr proteinMacrophage Galactose-Type Lectin proteinMgl proteinMacrophage Lectin 2 proteinCd Antigen Cd301 proteinCLEC10A proteinCLECSF13 proteinCLECSF14 proteinHML protein |
Information sourced from Uniprot.org
