| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human CD264/TNFRSF10D/TRAIL-R4-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit TRAIL mediated cytotoxicity using mouse fibroblast cells (L-929) treated with TRAIL. The ED50 for this effect is 1.8-7.2 ng/mL in the presence of 20 ng/mL. |
| Gene Symbol: | TNFRSF10D |
| Gene ID: | 8793 |
| Uniprot ID: | TR10D_HUMAN |
| Immunogen Region: | Ala56-His211 |
| Immunogen: | Homo sapiens (Human) |
| Function | Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. it cannot but it can induce the NF-kappa-B pathway. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10dDecoy Receptor 2Dcr2Tnf-Related Apoptosis-Inducing Ligand Receptor 4Trail Receptor 4Trail-R4Trail Receptor With A Truncated Death DomainCd Antigen Cd264 |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6803211Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 10d proteinDecoy Receptor 2 proteinDcr2 proteinTnf-Related Apoptosis-Inducing Ligand Receptor 4 proteinTrail Receptor 4 proteinTrail-R4 proteinTrail Receptor With A Truncated Death Domain proteinCd Antigen Cd264 proteinTNFRSF10D proteinDCR2 proteinTRAILR4 proteinTRUNDD proteinUNQ251 proteinPRO288 protein |
Information sourced from Uniprot.org
