| Post Translational Modifications | Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated. |
| Function | Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11. |
| Protein Name | C-X-C Chemokine Receptor Type 3Cxc-R3Cxcr-3Ckr-L2G Protein-Coupled Receptor 9Interferon-Inducible Protein 10 ReceptorIp-10 ReceptorCd Antigen Cd183 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Cell Membrane |
| Alternative Protein Names | C-X-C Chemokine Receptor Type 3 proteinCxc-R3 proteinCxcr-3 proteinCkr-L2 proteinG Protein-Coupled Receptor 9 proteinInterferon-Inducible Protein 10 Receptor proteinIp-10 Receptor proteinCd Antigen Cd183 proteinCXCR3 proteinGPR9 protein |
Information sourced from Uniprot.org
