| Short Description : | Recombinant-Human CCL21/6Ckine-No-Tag protein was developed in pichia using the region Ser24-Pro134. For use in research applications. |
| Host: | Pichia |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | Please contact us for more information. |
| Gene Symbol: | CCL21 |
| Gene ID: | 6366 |
| Uniprot ID: | CCL21_HUMAN |
| Immunogen: | Recombinant Human CCL21/6Ckine Protein is produced by Pichia expression system. The target protein is expressed with sequence (Ser24-Pro134) of human CCL21/6Ckine (Accession #NP_002980.1) fused with no additional amino acid. |
| Immunogen Region: | Ser24-Pro134 |
| Immunogen Sequence: | SDGGAQDCCLKYSQRKIPAK VVRSYRKQEPSLGCSIPAIL FLPRKRSQAELCADPKELWV QQLMQHLDKTPSPQKPAQGC RKDRGASKTGKKGKGSKGCK RTERSQTPKGP |
| Function | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 216ckineBeta-Chemokine Exodus-2Secondary Lymphoid-Tissue ChemokineSlcSmall-Inducible Cytokine A21 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 21 protein6ckine proteinBeta-Chemokine Exodus-2 proteinSecondary Lymphoid-Tissue Chemokine proteinSlc proteinSmall-Inducible Cytokine A21 proteinCCL21 proteinSCYA21 proteinUNQ784 proteinPRO1600 protein |
Information sourced from Uniprot.org
