Human CCL19/MIP-3 beta protein (Recombinant) (T7-Tag) (STJP016720)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CCL19/MIP-3 beta-T7-Tag protein was developed from e.coli and has a target region of T7-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | CCL19 |
| Gene ID | 6363 |
| Uniprot ID | CCL19_HUMAN |
| Accession Number | NP_006265.1 |
| Immunogen | Human |
| Immunogen Region | 22-98aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach. |
| Function | May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 19Beta-Chemokine Exodus-3Ck Beta-11Epstein-Barr Virus-Induced Molecule 1 Ligand ChemokineEbi1 Ligand ChemokineElcMacrophage Inflammatory Protein 3 BetaMip-3-BetaSmall-Inducible Cytokine A19 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 19 proteinBeta-Chemokine Exodus-3 proteinCk Beta-11 proteinEpstein-Barr Virus-Induced Molecule 1 Ligand Chemokine proteinEbi1 Ligand Chemokine proteinElc proteinMacrophage Inflammatory Protein 3 Beta proteinMip-3-Beta proteinSmall-Inducible Cytokine A19 proteinCCL19 proteinELC proteinMIP3B proteinSCYA19 protein |
Information sourced from Uniprot.org