Human CCL17/TARC protein (Recombinant) (C-His) (STJP013541)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CCL17/TARC-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM His-HCl, 10% Trehalose, 5% Maltose, 100mM NaCl, 0.1% Tween 80, pH 6.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CCL17 |
| Gene ID | 6361 |
| Uniprot ID | CCL17_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala24Ser94 |
Additional Info
| Function | Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound. |
| Protein Name | C-C Motif Chemokine 17Cc Chemokine TarcSmall-Inducible Cytokine A17Thymus And Activation-Regulated Chemokine |
| Database Links | Reactome: R-HSA-380108 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 17 proteinCc Chemokine Tarc proteinSmall-Inducible Cytokine A17 proteinThymus And Activation-Regulated Chemokine proteinCCL17 proteinSCYA17 proteinTARC protein |
Information sourced from Uniprot.org