Human Cathepsin E protein (Recombinant) (His-Tag) (STJP018685)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Cathepsin E-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CTSE |
| Gene ID | 1510 |
| Uniprot ID | CATE_HUMAN |
| Accession Number | NP_683865 |
| Immunogen | Human |
| Immunogen Region | 57-363aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes. |
| Post Translational Modifications | Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide. Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57. |
| Function | May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. |
| Protein Name | Cathepsin E Cleaved Into - Cathepsin E Form I - Cathepsin E Form Ii |
| Database Links | Reactome: R-HSA-2132295 |
| Cellular Localisation | EndosomeThe Proenzyme Is Localized To The Endoplasmic Reticulum And Golgi ApparatusWhile The Mature Enzyme Is Localized To The Endosome |
| Alternative Protein Names | Cathepsin E Cleaved Into - Cathepsin E Form I - Cathepsin E Form Ii proteinCTSE protein |
Information sourced from Uniprot.org