| Host: |
E. coli |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris, 150mM NaCl, pH 8.0. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its esterase activity. The specific activity is >840 pmoles/min/Mu g, as measured with 1 mM 4-Nitrophenyl acetate and 0.1 Mu g enzyme at 400 nm in 100 Mu L of 12.5 mM Tris, 75 mM NaCl, pH 7.5. |
| Gene Symbol: |
CA2 |
| Gene ID: |
760 |
| Uniprot ID: |
CAH2_HUMAN |
| Immunogen Region: |
Ser2-Lys260 |
| Immunogen: |
Recombinant Human Carbonic anhydrase 2 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser2-Lys260) of human Carbonic anhydrase II (Accession #NP_000058.1). |
| Immunogen Sequence: |
SHHWGYGKHNGPEHWHKDFP IAKGERQSPVDIDTHTAKYD PSLKPLSVSYDQATSLRILN NGHAFNVEFDDSQDKAVLKG GPLDGTYRLIQFHFHWGSLD GQGSEHTVDKKKYAAELHLV HWNTKYGDFGKAVQQPDGLA VLGIFLKVGSAKPGLQKVVD VLDSIKTKGKSADFTNFDPR GLLPESLDYWTYPGSLTTPP LLECVTWIVLKEPISVSSEQ VLKFRKLNFNGEGEPEELM |
| Function | Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. |
| Protein Name | Carbonic Anhydrase 2Carbonate Dehydratase IiCarbonic Anhydrase CCacCarbonic Anhydrase IiCa-IiCyanamide Hydratase Ca2 |
| Database Links | Reactome: R-HSA-1237044Reactome: R-HSA-1247673Reactome: R-HSA-1475029 |
| Cellular Localisation | CytoplasmCell MembraneColocalized With Slc26a6 At The Surface Of The Cell Membrane In Order To Form A Bicarbonate Transport MetabolonDisplaced From The Cytosolic Surface Of The Cell Membrane By Pkc In Phorbol Myristate Acetate (Pma)-Induced Cells |
| Alternative Protein Names | Carbonic Anhydrase 2 proteinCarbonate Dehydratase Ii proteinCarbonic Anhydrase C proteinCac proteinCarbonic Anhydrase Ii proteinCa-Ii proteinCyanamide Hydratase Ca2 proteinCA2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
