| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit Anti-CD3-induced proliferation of jurkat cells. The ED50 for this effect is 3.35-13.4 ng/mL. |
| Gene Symbol: | BTN1A1 |
| Gene ID: | 696 |
| Uniprot ID: | BT1A1_HUMAN |
| Immunogen Region: | Ala27-Arg242 |
| Immunogen: | Recombinant Human BTN1A1/Butyrophilin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala 27-Arg 242) of human BTN1A1/Butyrophilin (Accession #NP_001723.2) fused with a 6×His tag at the C-terminus |
| Immunogen Sequence: | APFDVIGPPEPILAVVGEDA ELPCRLSPNASAEHLELRWF RKKVSPAVLVHRDGREQEAE QMPEYRGRATLVQDGIAKGR VALRIRGVRVSDDGEYTCFF REDGSYEEALVHLKVAALGS DPHISMQVQENGEICLECTS VGWYPEPQVQWRTSKGEKFP STSESRNPDEEGLFTVAASV IIRDTSAKNVSCYIQNLLLG QEKKVEISIPASSLPR |
| Function | May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. |
| Protein Name | Butyrophilin Subfamily 1 Member A1 Bt |
| Database Links | Reactome: R-HSA-8851680 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein Secreted |
| Alternative Protein Names | Butyrophilin Subfamily 1 Member A1 protein Bt protein BTN1A1 protein BTN protein |
Information sourced from Uniprot.org